Toenemend bewijs wijst op een verband tussen het darmmicrobioom en sarcopenie, de spierafbraak die gepaard gaat met veroudering. De mechanismen achter deze associaties zijn echter nog steeds onduidelijk, wat het translationele [...]
Geneesmiddelen als gero-protectors
Geroprotectors zijn verbindingen die de veroudering kunnen vertragen en een gezonde levensduur kunnen bevorderen. Hoewel honderden verbindingen gekend zijn die de levensduur van laboratoriumorganismen verlengen, zijn klinische [...]
De rol van aangeboren lymfocyten bij spierafbraak
Immunosenescentie omvat de veranderingen in immuniteit die gepaard gaan met veroudering. Die veranderingen zij zowel in het adaptieve als het aangeboren immuunsysteem. Het verouderde aangeboren immuunsysteem wordt bijvoorbeeld gekenmerkt [...]
Quorum sensing peptiden in het verouderde immuunsysteem
Quorum sensing peptides (QSPs) are characteristic bacterial products, constitutively produced by living bacteria and exhibiting an increased and/or altered production in “stress” conditions. They have long been considered as intra-bacterial […]
Studie naar speeksel metabolieten bij ouderen
Recente studies hebben verschillende bacteriële metabolieten geïdentificeerd in menselijk speeksel [1, 2]. De veranderingen in metabolieten bij het verouderen zijn echter nog niet goed gekarakteriseerd. Bij TRIGG optimaliseren we momenteel [...]
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