The article "Sample preparation in analytical peptidomics: It's all about timing" discusses how critical the timing and conditions of sample preparation are for accurate peptidomic analysis. Peptides are highly dynamic and susceptible to enzymatic degradation and chemical modifications shortly after sample collection. Even short delays or inappropriate handling can significantly alter the peptide profile, leading to biased or misleading results and conclusions. The authors emphasize the importance of rapid sample processing. They conclude that controlling time-sensitive steps is essential for preserving biological relevance and achieving reproducible, high-quality analytical data in peptidomics.
